United States securities and exchange commission logo

                          August 10, 2022

       John Dobak, M.D.
       Chief Executive Officer
       DermTech, Inc.
       11099 N. Torrey Pines Road, Suite 100
       La Jolla, CA 92037

                                                        Re: DermTech, Inc.
Statement on Form S-3
                                                            Filed August 8,
                                                            File No. 333-266650

       Dear Dr. Dobak:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Joshua
Gorsky at 202-551-7836 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Jeremy Glaser, Esq.